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15 companies that will change the world

These game-changing startups are likely to upend existing industries - and spawn new entrepreneurial opportunities.

Virgin Charter
With Virgin's online reservation system, Duffy aims to make booking a charter jet as easy as flying commercial.
Virgin Charter
CEO: Scott Duffy
Disruption: Online reservations for the budding air-taxi business
Disrupted: Commercial airlines

Air taxis - tiny, short-hop planes that are so affordable that business fliers can charter them whenever they want - are taking off. Virgin Charter, majority-owned by Richard Branson, aims to be the Expedia for this new market. By creating a portal that connects travelers to charter operators, most of whom are mom-and-pop shops, the company plans to bring more revenue into the industry, reduce the cost of operating air charter services, and waste less jet fuel.

Blinkx

Raydiance

Expensr

Zipcar

MFG.com

Virgin Charter

PatientsLikeMe

Bloom Energy

Vanu

Zink

A123 Systems

Renewable Energy Group

Desktop Factory

Cree

One laptop per child
The New Disruptors video series Editor-at-Large Erick Schonfeld discovers startups with the potential to overturn existing industries or open up entirely new markets. (more)
Tomorrow's light With companies developing innovative ways to fight global warming, Cree founder John Edmond describes how LED lights are poised to change the way we see things. (more) video
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